CML to AML

37 year old female, known case of BCR::ABL1 positive Chronic Myeloid Leukaemia- Chronic Phase since Feb 2021 (on Nilotinib 600mg/day since diagnosis)

Presented to AFIP with complaints of decreased appetite and increasing lethargy for the past one month. 

Parameter

Results

Reference Range

TLC

25.19 Ç

4.0 – 10.0 x 109/L

RBC

3.45

3.8 – 5.8 x 1012 /L

Haemoglobin

11.4

13.0 – 17.0 g/dl

HCT

34.4

37 – 47 %

MCV

99.7

76.0 – 96.0 fl

MCH

33.0

27.0 – 32.0 pg

MCHC

33.1

31.5 – 34.5 g/dl

Platelet Count

50 È

150 – 400 x 109/L

 

WBCs

Percentage%

Neutrophils

07

Lymphocytes

20

Monocytes

01

Myelocytes

02

Blast Cells

70

 

 

 

Final Diagnosis: Chronic Myeloid Leukaemia in Blast Crisis (Acute Megakaryoblastic)